How Electron Cryotomography is Opening a New Window into Microbial Ultrastructure

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Date/Time:Monday, 15 Oct 2012 from 4:10 pm to 5:00 pm
Location:Physics 0005
Phone:515-294-5441
Channel:College of Liberal Arts and Sciences
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Grant Jensen (Caltech, HHMI)

Electron cryotomography (ECT) is an emerging technology that allows small cells to be imaged in 3-D in an intact, near-native state to "molecular" (5-2 nm) resolution. The basic principles of ECT will be explained as well as its future promises and limitations. Example results that have helped us understand the structural biology/biophysics of microbial cell shape determination, motility, chemotaxis, division, and interspecies attack will be shown.