Single Molecule Imaging of the Dynamic Organization of Cellular Membranes

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Date/Time:Monday, 24 Mar 2014 from 4:10 pm to 5:00 pm
Location:Physics 0003
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Ken Ritchie Purdue

Abstract: All living cells are encapsulated by an outer envelope that contains a fluid phospholipid-based membrane. Embedded within this membrane is the machinery (proteins) required for the cell to sense and interact with its environment. As such, one postulates that there may be mechanisms in place to control the location and mobility of the membrane proteins in the fluid membrane in order to perform these sometimes complex and critical tasks. In this talk, I will present our group's recent single molecule mobility studies into the (dynamic) organization of the cellular membranes of E. coli bacteria performed at acquisition rates up to 1 kHz. Examples will include the structure of the polar region of the inner membrane as seen by the serine chemoreceptor Tsr and investigations into interactions of the iron transporter FepA in the E. coli outer membrane with the inner membrane protein TonB.

Bio: Kenneth Patrick Ritchie is a Professor in the Department of Physics at Purdue University. He received his PhD in Physics from the University of British Columbia in 1998 and his MS from the University of Waterloo in 1992.