Statistics Seminar
| Date/Time: | Monday, 20 Apr 2015 from 4:10 pm to 5:00 pm |
|---|---|
| Location: | Snedecor 3105 |
| Cost: | Free |
| URL: | www.stat.iastate.edu |
| Contact: | Main Office |
| Phone: | 515-294-3440 |
| Channel: | College of Liberal Arts and Sciences |
| Categories: | Lectures |
| Actions: | Download iCal/vCal | Email Reminder |
Case-control design is widely used in epidemiology and other fields to identify factors associated with a disease. Data collected from existing case-control studies can also provide a cost-effective way to investigate the association of risk factors with secondary outcomes. When the secondary outcome is a continuous random variable, most of the existing methods focus on the statistical inference on the mean of the secondary outcome. In this paper, we propose a quantile-based approach to facilitating a comprehensive investigation of covariates' effects on multiple quantiles of the secondary outcome. We construct a new family of estimating equations combining observed and pseudo outcomes, which lead to consistent estimation of conditional quantiles using case-control data. Simulations are conducted to evaluate the performance of our proposed approach, and a case-control study on genetic association with asthma is used to demonstrate the method.