Seminar: Nanovaccine Initiative and Immunobiology Graduate Program
| Date/Time: | Friday, 18 Sep 2015 from 1:10 pm to 2:00 pm |
|---|---|
| Location: | 2542 Veterinary Medicine |
| Cost: | Free |
| URL: | http://www.nanovaccine.iastate.edu/seminars/ |
| Contact: | Cheryl Khoo |
| Phone: | 515-294-3533 |
| Channel: | Research |
| Categories: | Lectures |
| Actions: | Download iCal/vCal | Email Reminder |
Abstract
A limitation in translational research in the gastrointestinal tract has been the absence of models that recapitulate the diverse nature of the intestinal epithelium. Recently, human intestinal enteroids (HIEs) have been established and contain the normal complement of epithelial cell types (stem, enterocyte, goblet, enteroendocrine, and Paneth cells). We have utilized HIE cultures as pre-clinical models to study the response of the epithelium to common enteric viral pathogens such as human rotavirus (HRV), which kills nearly 500,000 children annually by causing dehydrating gastroenteritis. Studies on HRVs have been limited because they are difficult to culture in transformed cell lines and do not infect small animals. HRVs predominately infect and replicate in the mature enterocytes in the small intestine.