Seminar: Nanovaccine Initiative and Immunobiology Graduate Program

Su Mo Tu We Th Fr Sa
30 31 1 2 3 4 5
6 7 8 9 10 11 12
13 14 15 16 17 18 19
20 21 22 23 24 25 26
27 28 29 30 1 2 3
Date/Time:Monday, 28 Sep 2015 from 4:10 pm to 5:00 pm
Location:1414 Molecular Biology
Cost:Free
URL:http://www.nanovaccine.iastate.edu/seminars/
Contact:Cheryl Khoo
Phone:515-294-3533
Channel:Research
Categories:Lectures
Actions:Download iCal/vCal | Email Reminder
"Tissue Resident Memory CD8 T Cells: Location and Function," David Masopust, University of Minnesota, Minneapolis. Masopust will discuss the relationships among T cell location, function, differentiation and immunological protection, with particular emphasis on mucosal responses and vaccine applications. Refreshments will be provided.

Dr. Masopust's laboratory studies CD8 and CD4 T cell responses to a variety of viral and bacterial infections to help understand the development of immunological protection from re-infection. His lab observe and manipulate pathogen specific T cell responses over time by using MHC tetramers, adoptive transfer of transgenic T cells, fluorescence flow cytometry and sorting, and gene microarry analysis. Upon activation in lymphoid tissue, rare pathogen-specific naive T cells proliferate, acquire effector functions, disseminate throughout the organism, and contribute to the eradication of pathogens. In situations where antigen is successfully eliminated, most effector T cells die by apoptosis. However, a fraction of effector T cells escape death and differentiate into long-lived memory T cells that contribute to protective immunity. They are currently dedicated to elucidating the developmental cues that govern T cell migration to different anatomical locations, commitment to the memory lineage, and the contribution of memory T cell differentiation state and location to protection from re-infection. Memory T cells that reside at common portals of pathogen entry or infection, especially the intestinal mucosa, are of particular interest. By understanding these issues, they hope to contribute to the development of better vaccination strategies, and are currently focused on informing development of a protective HIV vaccine.