Seminar: Circadian clocks, sleep, and aging on the fly

Su Mo Tu We Th Fr Sa
31 1 2 3 4 5 6
7 8 9 10 11 12 13
14 15 16 17 18 19 20
21 22 23 24 25 26 27
28 29 30 1 2 3 4
Date/Time:Tuesday, 30 Apr 2024 from 1:00 pm to 1:50 pm
Location:1414 Molecular Biology
Contact:Danise Jones
Actions:Download iCal/vCal | Email Reminder
Join this Genetics, Development and Cell Biology seminar to hear Dr. Dae-Sung Hwangbo, assistant professor of genetics from the University of Louisville, discuss research utilizing the fruit fly as a model to understand how environmental factors regulate physiology and behavior, and eventually impact health and aging.

Full Description: Utilizing the fruit fly (Drosophila melanogaster) as a model organism, my lab aims to understand how environmental factors (such as diet, light, and temperature) regulate physiology (including circadian rhythms and metabolism) and behavior (such as sleep and feeding), and eventually impact health and aging. This seminar will provide an overview of our lab's research program, focusing on how the circadian clocks in the periphery interact with dietary restriction (DR) to regulate lifespan. DR, the reduction of food intake without causing malnutrition, is known as one of the most robust ways to promote health and lifespan. We have found that the core clock transcription factor, CLOCK, plays a critical role in lifespan extension by DR. A time-series RNA-Seq analysis of samples from abdominal fat bodies, followed by a functional RNAi-mediated lifespan screen, identified the proteasome as a main output target of the clock in the fat body that regulates lifespan. We propose that DR reprograms the rhythmic transcription of clock output genes, such as the proteasome genes, to extend lifespan.