Seminar: Time flies, how? Unlocking the secrets of aging
| Date/Time: | Tuesday, 03 Dec 2024 from 1:00 pm to 1:50 pm |
|---|---|
| Location: | 1414 Molecular Biology |
| Cost: | Free |
| Contact: | Danise Jones |
| Phone: | 515-294-6821 |
| Channel: | Research |
| Categories: | Lectures |
| Actions: | Download iCal/vCal | Email Reminder |
Synopsis: Aging phenotypes have been observed and described for centuries and a number of different aging hypotheses have been proposed. However, several critical questions remain largely unaddressed in complex organisms. For example, do different cell types age at different rates? If yes, which cell types age the fastest across the whole body? Here I will present our recent work on the Aging Fly Cell Atlas, the first single-nucleus transcriptomic map of the whole aging organism. We characterize 163 distinct cell types and perform an in-depth analysis of changes in tissue cell composition, gene expression, and cell identities. This study provides a fresh insight in organism-level aging rate at cellular resolution.