Toward Single-Macromolecule 3D Imaging with Intense, Short-Pulse X-ray Lasers

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Date/Time:Monday, 25 Oct 2010 from 2:10 pm to 3:00 pm
Location:Rroom 18/19 Physics
Channel:Condensed Matter Physics
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Changyong Song RIKEN SPring-8 Center, Japan

Coherent x-ray diffraction microscopy (CDM), by overcoming the contingent dependency on a crystalline specimen, has spawned wealth of its applications in biology and materials science. Over the last decade the technique has evolved to address certain scientific issues: imaging of buried nanostructures with element specificity and noninvasive 3D imaging of cells and organelles at a few tens of nanometer resolution. CDM bears the potential to facilitate near atomic resolution imaging from single-macromolecule specimens. Insufficient coherent photon flux, however, and a radiation damage of specimens have delayed its realization. X-ray Free Electron Lasers (XFELs) are under active constructions presently to deliver intense, short-pulse coherent x-rays. These XFELs expect to empower CDM to pave a solid route to 3D imaging of single macromolecules. In this talk, we will introduce coherent x-ray diffractive imaging activities at SPring-8. A prospect on single-molecule imaging with the Japan XFEL will be discussed by extending our recent progress on imaging unstained single virus.