Osborn Club lecture
| Date/Time: | Monday, 21 Mar 2011 at 7:00 pm |
|---|---|
| Location: | Gold Room, Hilton Garden Inn, 1325 Dickenson Ave., Ames |
| Cost: | Free |
| URL: | http://www.ent.iastate.edu/osbornclub/programs |
| Contact: | James Reecy, |
| Phone: | 515-294-9269 |
| Channel: | Groups, governance |
| Categories: | Lectures |
| Actions: | Download iCal/vCal | Email Reminder |
Abstract
Emerging and remerging viral diseases, such as the Ebola and Marburg hemorrhagic fevers, are a significant threat to human health and are potential agents of bioterrorism. Ebola viral (EBOV) infections simultaneously suppress the host innate and adaptive immune systems, which lead to severe viral hemorrhagic fever and high fatality rates in humans. However, no approved vaccines or treatments are currently available to counter these infections, in part due to the paucity of knowledge on viral components. Multifunctional filoviral protein 35 (VP35) has emerged as a critical viral component important for infection, immune evasion and pathogenesis. Using a combination of structural, biochemical and cell biological studies, we recently delineated mechanisms by which pathogenic viruses such as the ebolavirus evade host immunity. These studies, as well as recent results of structure-based diagnostic and therapeutic development, will be discussed.
About the Osborn Club
The Osborn Research Club was founded in 1921 and named in honor of Dr. Herbert Osborn. Members of the club are active researchers within the natural or physical sciences, and the club provides a forum for exchange of ideas across scientific disciplines. Club members meet monthly from September through May for a program consisting of a social period, dinner and presentation of a research lecture. The lecture portion of the program is open to the public.