Seminar: Mechanisms of aging: from inter-organ communication to inter-organelle cross-talk
|Date/Time:||Thursday, 30 Sep 2021 from 3:00 am to 3:50 am|
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Join this zoom to hear from Dr. Hua Bai, Assistant Professor in the Department of Genetics, Development and Cell Biology.
Synopsis: Inter-organ and inter-organelle communication play an important role in cellular and tissue homeostasis. Dr. Bai will present recent and unpublished work on the novel roles of peroxisome in liver-heart communication and mitochondrial dynamics during animal aging. Peroxisomes are essential and yet least studied subcellular organelles of all eukaryotic cells. They play a crucial role in the regulation of cellular redox homeostasis, oxidation of very long chain fatty acids (VLCFAs), and biosynthesis of ether phospholipid. Recent studies demonstrated that peroxisomal deficiency is a major cause of aging and that the interplay between peroxisomes and other organelles (e.g., mitochondria) play a crucial role in cellular homeostasis during animal aging.